Uniformity and Diversity in Handaxe Shape at the End of the Acheulean in Southwest Asia

This study examines parameters, causes, and spatio-temporal patterns of handaxe shape variation from Tabun cave in the Levant, and Khall Amayshan 4B and Khabb Musayyib in northern Arabia. These assemblages span the range of most pointy to most rounded handaxes found anywhere during the Acheulean. The AGMT3D program is used to conduct high resolution geometric morphometric analysis of handaxe form from 3D models. Shape variation is tested against blank type, allometry, and reduction intensity. None of these factors appears to be a strong influence, but there are significant assemblage-wise differences in form, suggesting the different shapes were intentionally produced. The analysis quantifies a pattern of high diversity in the assemblages from Tabun versus low diversity in the shorter occupations at the Arabian sites. We suggest possible explanations of emerging specificity in utilitarian functions, as well as the manifestation of social identities in artefacts at the end of the Acheulean

Physical activity as an aid to smoking cessation during pregnancy (LEAP) trial: study protocol for a randomized controlled trial

Background: Many women try to stop smoking in pregnancy but fail. One difficulty is that there is insufficient evidence that medications for smoking cessation are effective and safe in pregnancy and thus many women prefer to avoid these. Physical activity (PA) interventions may assist cessation; however, trials examining these interventions have been too small to detect or exclude plausible beneficial effects. The London Exercise And Pregnant smokers (LEAP) trial is investigating whether a PA intervention is effective and cost-effective when used for smoking cessation by pregnant women, and will be the largest study of its kind to date. Methods/design: The LEAP study is a pragmatic, multi-center, two-arm, randomized, controlled trial that will target pregnant women who smoke at least one cigarette a day (and at least five cigarettes a day before pregnancy), and are between 10 and 24 weeks pregnant. Eligible patients are individually randomized to either usual care (that is, behavioral support for smoking cessation) or usual care plus a intervention (entailing supervised exercise on a treadmill plus PA consultations). The primary outcome of the trial is self-reported and biochemically validated continuous abstinence from smoking between a specified quit date and the end of pregnancy. The secondary outcomes, measured at 1 and 4 weeks after the quit date, and at the end of pregnancy and 6 months after childbirth, are PA levels, depression, self-confidence, and cigarette withdrawal symptoms. Smoking status will also be self-reported at 6 months after childbirth. In addition, perinatal measures will be collected, including antenatal complications, duration of labor, mode of delivery, and birth and placental weight. Outcomes will be analyzed on an intention-to-treat basis, and logistic regression models used to compare treatment effects on the primary outcome. Discussion: This trial will assess whether a PA intervention is effective when used for smoking cessation during pregnancy

Plant virus particles carrying tumour antigen activate TLR7 and induce high levels of protective antibody

Induction of potent antibody is the goal of many vaccines targeted against infections or cancer. Modern vaccine designs that use virus-like particles (VLP) have shown efficacy for prophylactic vaccination against virus-associated cancer in the clinic. Here we used plant viral particles (PVP), which are structurally analogous to VLP, coupled to a weak idiotypic (Id) tumour antigen, as a conjugate vaccine to induce antibody against a murine B-cell malignancy. The Id-PVP vaccine incorporates a natural adjuvant, the viral ssRNA, which acts via TLR7. It induced potent protective anti-Id antibody responses in an in vivo mouse model, superior to the "gold standard" Id vaccine, with prevalence of the IgG2a isotype. Combination with alum further increased antibody levels and maintained the IgG2a bias. Engagement of TLR7 in vivo was followed by secretion of IFN-? by plasmacytoid dendritic cells and by activation of splenic CD11chi conventional dendritic cells. The latter was apparent from up-regulation of co-stimulatory molecules and from secretion of a wide range of inflammatory cytokines and chemokines including the Th1-governing cytokine IL-12, in keeping with the IgG2a antibody isotype distribution. PVP conjugates are a novel cancer vaccine design, offering an attractive molecular form, similar to VLP, and providing T-cell help. In contrast to VLP, they also incorporate a safe "in-built" ssRNA adjuvant

Why organizational and community diversity matter:Representativeness and the Emergence of Incivility and Organizational Performance

Integrating sociological and psychological perspectives, this research considers the value of organizational ethnic diversity as a function of community diversity. Employee and patient surveys, census data, and performance indexes relevant to 142 hospitals in the United Kingdom suggest that intraorganizational ethnic diversity is associated with reduced civility toward patients. However, the degree to which organizational demography was representative of community demography was positively related to civility experienced by patients and ultimately enhanced organizational performance. These findings underscore the understudied effects of community context and imply that intergroup biases manifested in incivility toward out-group members hinder organizational performance

Local diversity in settlement, demography and subsistence across the southern Indian Neolithic-Iron Age transition: site growth and abandonment at Sanganakallu-Kupgal

The Southern Indian Neolithic-Iron Age transition demonstrates considerable regional variability in settlement location, density, and size. While researchers have shown that the region around the Tungabhadra and Krishna River basins displays significant subsistence and demographic continuity, and intensification, from the Neolithic into the Iron Age ca. 1200 cal. BC, archaeological and chronometric records in the Sanganakallu region point to hilltop village expansion during the Late Neolithic and ‘Megalithic’ transition period (ca. 1400–1200 cal. BC) prior to apparent abandonment ca. 1200 cal. BC, with little evidence for the introduction of iron technology into the region. We suggest that the difference in these settlement histories is a result of differential access to stable water resources during a period of weakening and fluctuating monsoon across a generally arid landscape. Here, we describe well-dated, integrated chronological, archaeobotanical, archaeozoological and archaeological survey datasets from the Sanganakallu-Kupgal site complex that together demonstrate an intensification of settlement, subsistence and craft production on local hilltops prior to almost complete abandonment ca. 1200 cal. BC. Although the southern Deccan region as a whole may have witnessed demographic increase, as well as subsistence and cultural continuity, at this time, this broader pattern of continuity and resilience is punctuated by local examples of abandonment and mobility driven by an increasing practical and political concern with water

Final reports: Mechanics of complex materials, Summer 2004

The Mechanics of Complex Materials is a ten-week undergraduate research program hosted by the Department of Theoretical and Applied Mechanics at the University of Illinois at Urbana-Champaign. The dual purposes of this program are (1) to introduce undergraduate students from a broad background to modern problems in the mechanics of materials and (2) to encourage the students to attend graduate school and pursue a career in research. Support for the program is provided by the National Science Foundation and the Department of Defense, through the Research Experience for Undergraduates. [More ...]published or submitted for publicationis not peer reviewe

Large Flake Acheulean in the Nefud Desert of Northern Arabia

International audienceBetween the Levant and the Indian sub-continent only a few Acheulean sites have been documented, hampering models of hominin dispersals. Here we describe the first Acheulean sites to be discovered in the Nefud Desert of northern Arabia. The four sites occur in a variety of settings including adjacent to an alluvial fan drainage system, at a knappable stone source, and on the margins of endorheic basins. We discuss the implications of the sites for hominin landscape use, in particular the preferential transport and curation of bifaces to fresh water sources. The bifaces correspond to the Large Flake middle Acheulean in the Levantine sequence. The sites occupy a gap in the distribution of the Acheulean across the Saharo-Arabian arid belt, and as such have implications for dispersal routes between Africa and Asia

Large Flake Acheulean in the Nefud Desert of Northern Arabia

International audienceBetween the Levant and the Indian sub-continent only a few Acheulean sites have been documented, hampering models of hominin dispersals. Here we describe the first Acheulean sites to be discovered in the Nefud Desert of northern Arabia. The four sites occur in a variety of settings including adjacent to an alluvial fan drainage system, at a knappable stone source, and on the margins of endorheic basins. We discuss the implications of the sites for hominin landscape use, in particular the preferential transport and curation of bifaces to fresh water sources. The bifaces correspond to the Large Flake middle Acheulean in the Levantine sequence. The sites occupy a gap in the distribution of the Acheulean across the Saharo-Arabian arid belt, and as such have implications for dispersal routes between Africa and Asia